Bayesian Optimal Interval (BOIN) Design for Phase I Clinical Trials

PID: 979 ; V1.0.3.5 ; Last Updated: 05/23/2018


Yanhong Zhou, Suyu Liu, Ying Yuan and Heng Zhou

Department of Biostatistics, MD Anderson Cancer Center



How to Use the BOIN App

Doses






Error: Starting dose level must be less than the number of doses

Target Probability

Alternatives under which decision errors are minimized:




Sample Size

Overdose Control

Eliminate dose \(j\) if\(\ Pr\) (\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)




Simulation

Enter Simulation Scenarios




For each scenario, enter true toxicity rate of each dose level:








Target Toxicity Probability must be between 0 and 1

Error:You already reached the maximum number of doses you can enter!


Please enter the trial data:


Dose level
Number of patients treated
Number of patients with dose limiting toxicity