Bayesian Optimal Interval (BOIN) Design for Phase I Clinical Trials

V1.0.1 ; Last Updated: 11/03/2017

Yanhong Zhou, Suyu Liu, and Ying Yuan

Department of Biostatistics, MD Anderson Cancer Center

How to Use the BOIN App?


Error: Starting dose level must be less than the number of doses

Target Probability

Alternatives under which decision errors are minimized:

Sample Size

Overdose Control

Eliminate dose \(j\) if\(\ Pr\) (\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)


Enter Simulation Scenarios

For each scenario, enter true toxicity rate of each dose level:

Please make sure that you have set up Trial Setting and Simulation before generating the protocol.

Generate trial protocol with html file

Generate trial protocol with word file

Depending on the operating system, the size of the figure in the word protocol may vary. Please adjust accordingly after download.

Target Toxicity Probability must be between 0 and 1

Error:You already reached the maximum number of doses you can enter!

Please enter the trial data:

Dose level
Number of patients treated
Number of patients with dose limiting toxicity