Bayesian Optimal Interval (BOIN) Design for Phase I Clinical Trials

PID: 979 ; V1.0.3.5 ; Last Updated: 05/23/2018

Yanhong Zhou, Suyu Liu, Ying Yuan and Heng Zhou

Department of Biostatistics, MD Anderson Cancer Center

How to Use the BOIN App


Error: Starting dose level must be less than the number of doses

Target Probability

Alternatives under which decision errors are minimized:

Sample Size

Overdose Control

Eliminate dose \(j\) if\(\ Pr\) (\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)


Enter Simulation Scenarios

For each scenario, enter true toxicity rate of each dose level:

Target Toxicity Probability must be between 0 and 1

Error:You already reached the maximum number of doses you can enter!

Please enter the trial data:

Dose level
Number of patients treated
Number of patients with dose limiting toxicity