Bayesian Optimal Interval Design (BOIN) for Drug Combination Trials

V1.0.0 ; Last Updated: 6/29/2017


Yanhong Zhou, Suyu Liu, and Ying Yuan

Department of Biostatistics, MD Anderson Cancer Center




How to Use the BOIN App for Combination Trial?

Doses



Error: Dose Levels for Drug A must be Less than that of Drug B!

Target Probability

Alternatives under which decision errors are minimized:



Sample Size

Enter the number of cohorts at each subtrial:

Overdose Control

Eliminate dose \(j\) if\(\ Pr\)(\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)




Simulation Setting

Enter Simulation Scenarios


For each scenario, enter true toxicity rate of each dose combination:

Scenario 1:


Scenario 2:


Scenario 3:


Scenario 4:


Scenario 5:


Scenario 6:


Scenario 7:


Scenario 8:


Scenario 9:


Scenario 10:


Error:You already reached the maximum number of scenarios you can enter!





Please make sure that you have set up Trial Setting and Simulation before generating the protocol.


Generate trial protocol with html file


Generate trial protocol with word file

Depending on the operating system, the size of the figure in the word protocol may vary. Please adjust accordingly after download.



Error:Dose Levels for Drug A must be Less than that of Drug B!


Enter the number of patients treated at each dose combination:

Enter the number of patients with toxicity at each dose combination:






Error:Dose Levels for Drug A must be Less than that of Drug B!


Enter the number of patients treated at each dose combination:

Enter the number of patients with toxicity at each dose combination: