# Bayesian Optimal Interval Design (BOIN) for Drug Combination Trials

#### Target Probability

Alternatives under which decision errors are minimized:

#### Sample Size

Enter the number of cohorts at each subtrial:

#### Overdose Control

Eliminate dose $$j$$ if$$\ Pr$$($$p_j$$> $$\phi$$ | $$data$$) > $$p_E$$

wrong input

Scenario 1:

Scenario 2:

Scenario 3:

Scenario 4:

Scenario 5:

Scenario 6:

Scenario 7:

Scenario 8:

Scenario 9:

Scenario 10:

### Please make sure that you have set up Trial Setting and Simulation before generating the protocol.

##### Error:Dose Levels for Drug A must be Less than that of Drug B!

Enter the number of patients treated at each dose combination:

Enter the number of patients with toxicity at each dose combination:

##### Error:Dose Levels for Drug A must be Less than that of Drug B!

Enter the number of patients treated at each dose combination:

Enter the number of patients with toxicity at each dose combination: