Keyboard: a novel Bayesian toxicity probability interval design for phase I clinical trial

V1.0.0 ; Last Updated: 6/17/2017


Yanhong Zhou and Ying Yuan

Department of Biostatistics, MD Anderson Cancer Center




How to Use the Keyboard App?

Doses




Error: Starting dose level must be less than the number of doses


Target Probability



Sample Size

Overdose Control

Eliminate dose \(j\) if\(\ Pr\) (\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)




Simulation

Enter Simulation Scenarios




For each scenario, enter true toxicity rate of each dose level:







Please make sure that you have set up Trial Setting and run Simulation before generating the protocol.


Generate trial protocol with html file


Generate trial protocol with word file

Target Toxicity Probability must be between 0 and 1

Error:You already reached the maximum number of doses you can enter!


Please enter the trial data:


Dose level
Number of patients treated
Number of patients with dose limiting toxicity