A Phase I/II Design to Identify Optimal Biological Dose for Molecularly Targeted Agents

V1.0.0; Last Updated: 06/29/2017

Rongji Mu1 and Ying Yuan2

1School of Statistics, East China Normal University, Shanghai 200241, China

2Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030



Trial Setting



The value must be grater than 0.

The value must be less than 1.

A dose is deemed unaccepbly if \(\ Pr\) ( \(p_j\)> \(\phi\) | \(data\) ) > \(p_E\)

Enter Simulation Scenario



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Trial Setting



The value must be grater than 0.

The value must be less than 1.

Current dose level must be less than or equal to the total number of doses.

Current dose level must be greater than 0.

A dose is deemed unaccepbly if \(\ Pr\) ( \(p_j\)> \(\phi\) | \(data\) ) > \(p_E\)




Error:You already reached the maximum number of doses you can Input!

Enter Trial Data



Dose Level
# of Pts treated
# of DLT
# of response