PID:966; V.1.0.1; Last Updated: 03/15/2018
Sample Size Calculation - Continuous Endpoint
Developed by Haitao Pan and Ying Yuan
Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030
Number of Groups:
One
Two
> Two
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Test Objective:
Equality
Equivalence
Non-Inferiority/Superiority
1 or 2 Sided Test?
1-Sided
2-Sided
Equivalence Margin
Superiority/Non-Inferiority Margin
Null Hypothesis Mean (\(\mu_0\))
Alternative Hypothesis Mean (\(\mu_1\))
Std. Deviation (\(\sigma\)):
Test Objective:
Equality
Equivalence
Non-Inferiority/Superiority
1 or 2 Sided Test?
1-Sided
2-Sided
Equivalence Margin
Superiority/Non-Inferiority Margin
Absolute Mean Response Difference between Two Groups
Pooled Std. Deviation (\(\sigma\))
Allocation Ratio of Group 2 to Group 1
Design Type:
Balanced one-way ANOVA Tests
Number of Groups:
Effect Size
Type I Error (\(\alpha\)):
Power:
Sum of variance components
Clinically meaningful difference
Bonferroni adjust. for alpha (m)
Type I Error (\(\alpha\)):
Type II Error (\(\beta\)):
Type I Error (\(\alpha\)):
Type II Error (\(\beta\)):
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Results: