A Baysian design for phase II clinical trials with delayed responses based on multiple imputation

Endpoint to be monitored

What is observable?
Stop the trial if$$\ Pr$$ ( $$p$$ > $$\phi_T$$ | $$data$$ ) > $$C_T$$, where $$C_T$$ is
Stop the trial if$$\ Pr$$ ( $$p$$ < $$\phi_E$$ | $$data$$ ) > $$C_E$$, where $$C_E$$ is
Stop the trial if$$\ Pr$$ ( $$p$$ > $$\phi$$ | $$data$$ ) > $$C$$, where $$C$$ is
Evaluation time period for the endpoint