A Baysian design for phase II clinical trials with delayed responses based on multiple imputation

v1.0.0 ; Last updated: 06/15/2017


Chunyan Cai, Heng Zhou and Ying Yuan

Department of Biostatistics, MD Anderson Cancer Center




Endpoint to be monitored

What is observable?
Stop the trial if\(\ Pr\) ( \(p\) > \(\phi_T\) | \(data\) ) > \(C_T\), where \(C_T\) is
Stop the trial if\(\ Pr\) ( \(p\) < \(\phi_E\) | \(data\) ) > \(C_E\), where \(C_E\) is
Stop the trial if\(\ Pr\) ( \(p\) > \(\phi\) | \(data\) ) > \(C\), where \(C\) is
Evaluation time period for the endpoint



Interim Data